Prof. Dr. Aljoscha Wahl
Prof. Dr. Aljoscha Wahl
Postadresse:
Paul-Gordan-Str. 3
91052 Erlangen
Aktuelle Position:
W2-Professor für Systembiotechnologie | seit 01/2022 | Lehrstuhl für Bioverfahrenstechnik, FAU Erlangen-Nürnberg |
Kurz-Lebenslauf:
Assistant Professor | 2008 – 2021 | TU Delft, Department of Biotechnology, Niederlande Link zur Webseite von S. A. Wahl |
Postdoktorand | 2006 – 2008 | Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany, Bioprocess Engineering group, Prof. U. Reichl |
Doktorarbeit |
2007 |
„Methoden zur integrierten Analyse metabolischer Netzwerke unter stationären und instationären Bedingungen“ (Betreuung durch Prof. Wiechert, FZ Jülich) |
wiss. Mitarbeiter |
2003 – 2006 |
Institut für Biotechnologie 2, Forschungszentrum Jülich, Jülich – Prof. Wandrey und Prof. Wiechert |
Diplom |
1997 – 2003 |
Studium der Bioverfahrenstechnik, TU Dresden |
Editorial Board Memberships:
seit 2016 |
Scientific Reports |
seit 2010 |
Applied and Environmental Microbiology (two terms) |
Guest Editor – special edition:
Special Issue „Metabolic Functionality of Microorganisms under Dynamic Environments“ |
Publikationen:
2023
Using Kinetic Modelling to Infer Adaptations in Saccharomyces cerevisiae Carbohydrate Storage Metabolism to Dynamic Substrate Conditions
In: Metabolites 13 (2023), Art.Nr.: 88
ISSN: 2218-1989
DOI: 10.3390/metabo13010088
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Comparative proteome analysis of different Saccharomyces cerevisiae strains during growth on sucrose and glucose
In: Scientific Reports 13 (2023), Art.Nr.: 2126
ISSN: 2045-2322
DOI: 10.1038/s41598-023-29172-0
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2022
Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
In: Biotechnology and Bioengineering (2022)
ISSN: 0006-3592
DOI: 10.1002/bit.28193
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Kinetic Modeling of Saccharomyces cerevisiae Central Carbon Metabolism: Achievements, Limitations, and Opportunities
In: Metabolites 12 (2022), Art.Nr.: 74
ISSN: 2218-1989
DOI: 10.3390/metabo12010074
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Predicting Metabolic Adaptation Under Dynamic Substrate Conditions Using a Resource-Dependent Kinetic Model: A Case Study Using Saccharomyces cerevisiae
In: Frontiers in Molecular Biosciences 9 (2022), Art.Nr.: 863470
ISSN: 2296-889X
DOI: 10.3389/fmolb.2022.863470
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2021
Simultaneous quantification of the concentration and carbon isotopologue distribution of polar metabolites in a single analysis by gas chromatography and mass spectrometry
In: Analytical Chemistry 93 (2021), S. 8248-8256
ISSN: 0003-2700
DOI: 10.1021/acs.analchem.1c01040
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Prospects for multi-omics in the microbial ecology of water engineering
In: Water Research 205 (2021), Art.Nr.: 117608
ISSN: 0043-1354
DOI: 10.1016/j.watres.2021.117608
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An NADH preferring acetoacetyl-CoA reductase is engaged in poly-3-hydroxybutyrate accumulation in Escherichia coli
In: Journal of Biotechnology 325 (2021), S. 207-216
ISSN: 0168-1656
DOI: 10.1016/j.jbiotec.2020.10.022
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Resource allocation explains lactic acid production in mixed-culture anaerobic fermentations
In: Biotechnology and bioengineering 118 (2021), S. 745-758
ISSN: 1097-0290
DOI: 10.1002/bit.27605
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Aerobic growth physiology of Saccharomyces cerevisiae on sucrose is strain-dependent
In: Fems Yeast Research 21 (2021), Art.Nr.: foab021
ISSN: 1567-1356
DOI: 10.1093/femsyr/foab021
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2020
Escherichia coli metabolism under short-Term repetitive substrate dynamics: Adaptation and trade-offs
In: Microbial Cell Factories 19 (2020), Art.Nr.: 116
ISSN: 1475-2859
DOI: 10.1186/s12934-020-01379-0
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Dynamics in redox metabolism, from stoichiometry towards kinetics
In: Current Opinion in Biotechnology 64 (2020), S. 116-123
ISSN: 0958-1669
DOI: 10.1016/j.copbio.2020.01.002
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Alpha-ketoglutarate utilization in Saccharomyces cerevisiae: transport, compartmentation and catabolism
In: Scientific Reports 10 (2020), Art.Nr.: 12838
ISSN: 2045-2322
DOI: 10.1038/s41598-020-69178-6
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Revealing the Metabolic Flexibility of “Candidatus Accumulibacter phosphatis” through Redox Cofactor Analysis and Metabolic Network Modeling
In: Applied and Environmental Microbiology 86 (2020), S. 1-17
ISSN: 0099-2240
DOI: 10.1128/AEM.0808-20
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2019
Modelling cell-free RNA and protein synthesis with minimal systems
In: Physical Biology 16 (2019), Art.Nr.: 025001
ISSN: 1478-3967
DOI: 10.1088/1478-3975/aaf33d
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Unraveling energy homeostasis in a dynamic model of glycolysis in Escherichia coli
18th European Control Conference, ECC 2019 (Naples, 25. Juni 2019 - 28. Juni 2019)
In: 2019 18th European Control Conference, ECC 2019 2019
DOI: 10.23919/ECC.2019.8795884
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Metabolism of sucrose in a non-fermentative Escherichia coli under oxygen limitation
In: Applied Microbiology and Biotechnology 103 (2019), S. 6245-6256
ISSN: 0175-7598
DOI: 10.1007/s00253-019-09909-6
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Grand Research Challenges for Sustainable Industrial Biotechnology
In: Trends in Biotechnology 37 (2019), S. 1042-1050
ISSN: 0167-7799
DOI: 10.1016/j.tibtech.2019.04.002
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Metabolic switches from quiescence to growth in synchronized Saccharomyces cerevisiae
In: Metabolomics 15 (2019), Art.Nr.: 121
ISSN: 1573-3882
DOI: 10.1007/s11306-019-1584-4
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2017
Membrane potential independent transport of NH3 in the absence of ammonium permeases in Saccharomyces cerevisiae
In: BMC Systems Biology 11 (2017), Art.Nr.: 49
ISSN: 1752-0509
DOI: 10.1186/s12918-016-0381-1
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2016
Accurate measurement of the in vivo ammonium concentration in Saccharomyces cerevisiae
In: Metabolites 6 (2016), Art.Nr.: 12
ISSN: 2218-1989
DOI: 10.3390/metabo6020012
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Excessive by-product formation: A key contributor to low isobutanol yields of engineered Saccharomyces cerevisiae strains
In: Metabolic Engineering Communications 3 (2016), S. 39-51
ISSN: 2214-0301
DOI: 10.1016/j.meteno.2016.01.002
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Natural isotope correction of MS/MS measurements for metabolomics and 13C fluxomics
In: Biotechnology and Bioengineering 113 (2016), S. 1137-1147
ISSN: 0006-3592
DOI: 10.1002/bit.25859
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Interaction of storage carbohydrates and other cyclic fluxes with central metabolism: A quantitative approach by non-stationary 13C metabolic flux analysis
In: Metabolic Engineering Communications 3 (2016), S. 52-63
ISSN: 2214-0301
DOI: 10.1016/j.meteno.2016.01.001
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Current state and challenges for dynamic metabolic modeling
In: Current Opinion in Microbiology 33 (2016), S. 97-104
ISSN: 1369-5274
DOI: 10.1016/j.mib.2016.07.008
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2015
Thermodynamics-based design of microbial cell factories for anaerobic product formation
In: Trends in Biotechnology 33 (2015), S. 534-546
ISSN: 0167-7799
DOI: 10.1016/j.tibtech.2015.06.010
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Functional expression of a heterologous nickel-dependent, ATP-independent urease in Saccharomyces cerevisiae
In: Metabolic Engineering 30 (2015), S. 130-140
ISSN: 1096-7176
DOI: 10.1016/j.ymben.2015.05.003
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MetDFBA: Incorporating time-resolved metabolomics measurements into dynamic flux balance analysis
In: Molecular bioSystems 11 (2015), S. 137-145
ISSN: 1742-2051
DOI: 10.1039/c4mb00510d
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A fast sensor for in vivo quantification of cytosolic phosphate in Saccharomyces cerevisiae
In: Biotechnology and Bioengineering 112 (2015), S. 1033-1046
ISSN: 0006-3592
DOI: 10.1002/bit.25516
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Determination of the Cytosolic NADPH/NADP Ratio in Saccharomyces cerevisiae using Shikimate Dehydrogenase as Sensor Reaction
In: Scientific Reports 5 (2015), Art.Nr.: 12846
ISSN: 2045-2322
DOI: 10.1038/srep12846
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2014
Flux response of glycolysis and storage metabolism during rapid feast/famine conditions in Penicillium chrysogenum using dynamic 13C labeling
In: Biotechnology Journal 9 (2014), S. 372-385
ISSN: 1860-6768
DOI: 10.1002/biot.201200260
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An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme
In: Molecular Microbiology 93 (2014), S. 369-389
ISSN: 0950-382X
DOI: 10.1111/mmi.12666
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Lost in transition: Start-up of glycolysis yields subpopulations of nongrowing cells
In: Science 343 (2014), Art.Nr.: 1245114
ISSN: 0036-8075
DOI: 10.1126/science.1245114
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Flux response of glycolysis and storage metabolism during rapid feast/famine conditions in penicillium chrysogenum using dynamic 13C labeling
Metabolic Engineering X (Vancouver, BC, 15. Juni 2014 - 19. Juni 2014)
In: Metabolic Engineering X 2014
:
Quantitative metabolomics using ID-MS
In: Jens O. Krömer, Lars K. Nielsen, Lars M. Blank (Hrsg.): Metabolic Flux Analysis, Humana Press Inc., 2014, S. 91-105 (Methods in Molecular Biology, Bd.1191)
DOI: 10.1007/978-1-4939-1170-7_6
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2013
Glucose-methanol co-utilization in Pichia pastoris studied by metabolomics and instationary 13C flux analysis
In: Bmc Systems Biology 7 (2013), Art.Nr.: 17
ISSN: 1752-0509
DOI: 10.1186/1752-0509-7-17
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2012
Piecewise affine approximations of fluxes and enzyme kinetics from in vivo 13C labeling experiments
In: International Journal of Robust and Nonlinear Control 22 (2012), S. 1120-1139
ISSN: 1049-8923
DOI: 10.1002/rnc.2798
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A toolkit to enable hydrocarbon conversion in aqueous environments
In: Journal of Visualized Experiments (2012)
ISSN: 1940-087X
DOI: 10.3791/4182
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Similar temperature dependencies of glycolytic enzymes: An evolutionary adaptation to temperature dynamics?
In: BMC Systems Biology 6 (2012), Art.Nr.: 151
ISSN: 1752-0509
DOI: 10.1186/1752-0509-6-151
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Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum
In: Eukaryotic Cell 11 (2012), S. 238-249
ISSN: 1535-9778
DOI: 10.1128/EC.05285-11
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Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis
In: Microbial Cell Factories 11 (2012), Art.Nr.: 140
ISSN: 1475-2859
DOI: 10.1186/1475-2859-11-140
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2011
Metabolic adaptation of MDCK cells to different growth conditions: Effects on catalytic activities of central metabolic enzymes
In: Biotechnology and Bioengineering 108 (2011), S. 2691-2704
ISSN: 0006-3592
DOI: 10.1002/bit.23215
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2010
Expression, purification, and characterization of a His6-tagged glycerokinase from Pichia farinosa for enzymatic cycling assays in mammalian cells
In: Journal of Biotechnology 150 (2010), S. 396-403
ISSN: 0168-1656
DOI: 10.1016/j.jbiotec.2010.09.963
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Measurement of key metabolic enzyme activities in mammalian cells using rapid and sensitive microplate-based assays
In: Biotechnology and Bioengineering 107 (2010), S. 566-581
ISSN: 0006-3592
DOI: 10.1002/bit.22817
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Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling
In: Bmc Systems Biology 4 (2010), Art.Nr.: 61
ISSN: 1752-0509
DOI: 10.1186/1752-0509-4-61
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